The show discusses historical medical practices and unusual medical cases. Occasionally, sexual assault will be mentioned, but never in graphic detail. Medical malpractice and pseudoscience is a main theme, and many episodes discuss malpractice used specifically to discriminate against and abuse marginalized communities, often in the form of restricting their bodily autonomy. (For example, discussing the practice of forcibly sterilizing Black women in the United States during the 20th century.) These sorts of incidents are discussed with as little graphic detail as possible, and trigger warnings are usually given in the show notes or at the start of the episode.